Caveolin-1 Confers Resistance of Hepatoma Cells to Anoikis by Activating IGF-1 Pathway
Tang Wenqing
Feng Xuemei
Zhang Si
Ren Zheng-Gang
Liu Yin-Kun
Yang Biwei
Lv Bei
Cai Yu
Xia Jinglin
Ge Ning-Ling
· 2015
期刊名称：
Cellular Physiology and Biochemistry
2015 年
36 卷
3 期
摘要：
Background/Aims: Anoikis resistance is a prerequisite for hepatocellular carcinoma (HCC) metastasis. The role of Caveolin-1 (CAV1) in anoikis resistance of HCC remains unclear. Methods: The oncogenic effect of CAV1 on anchor-independent growth and anoikis resistance was investigated by overexpression and knockdown of CAV1 in hepatoma cells. IGF-1 pathway and its downstream signals were detected by immunoblot analysis. Caveolae invagination and IGF-1R internalization was studied by electron microscopy and
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