The chemopreventive potential of lycopene against atrazine-induced cardiotoxicity: Modulation of ionic homeostasis
Lin Jia
Li Hui-Xin
Xia Jun
Li Xue-Nan
Jiang Xiu-Qing
Zhu Shi-Yong
Ge Jing
Li J.L.
· 2016
期刊名称：
Scientific Reports
2016 年
6 卷
摘要：
People who drink water contaminated with atrazine (ATR) over many years can experience problems with their cardiovascular system. Lycopene (LYC) has been shown to exhibit cardiovascular disease preventive effects. However, chemopreventive potential of LYC against ATR-induced cardiotoxicity remains unclear. To determine the effects of ATR and/or LYC on heart, mice were treated with ATR (50 mg/kg or 200 mg/kg) and/or LYC (5 mg/kg) by intragastric administration for 21 days. Histopathological and biochemical analyses, including analysis of ion concentrations (Na
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